Effect of Andrographolide Co-Administration on Pharmacokinetics of Meloxicam in Rats

Meloxicam is a non-steroidal antiinflammatory drug from the subgroup of enolic acid oxicams. Meloxicam is a novel NSAID that has effectively replaced the old pain killers particularly diclofenac sodium which has high toxicity. Meloxicam has a high intrinsic activity combined with a low ulcerogenic potential (i.e. a high therapeutic index) (Engelhardt et al., 1996).Meloxicam is considered as standard non-steroidal antiinflammatory drug which metabolized by the cytochrome P450 (CYP) subgroup of isoenzymes, possibly CYP2C9/2C8 and CYP3A4 (Schmid et al., 1995; Chesné et al., 1998). Andrographolide (diterpene lactone) is main chemical constituent of plant Andrographis paniculata. It is widely used as home remedies against various aliments like throat infection, pneumonia, tonsillitis, dysentery, gastroenteritis and pyelonephritis (Deng et al., 1982). Moreover, it is reported that andrographolide modulate expression of several cytochromes P450 isoenzymes like CYP2C9, CYP3A4, CYP2C6/11, CYP1A1/2 and CYP3A1/2. (Chesné et al., 1998; Schmidet al., 1995; Pekthong et al., 2008; International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 10 (2017) pp. 2147-2153 Journal homepage: http://www.ijcmas.com